ncRNA name | MIAT |
ncRNA Category | lncRNA |
ID | 440823 |
Ensembl | ENSG00000225783 |
Synonyms | C22orf35, FLJ25967, LINC00066, NCRNA00066, Rncr2, gomafu, lncRNA-MIAT |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | plasma; human RPE cell line ARPE-19 |
Methods | qRT-PCR, ELISA, MTT assay, Western blot |
Expression pattern | up-regulated |
Functional description | Increased plasma levels of lncRNA-MIAT were significantly associated with the presence of diabetic retinopathy, and increased expression of lncRNA-MIAT reduced the viability of ARPE-19 cells in vitro by upregulating TGF-β1 signaling. |
PubMed ID | 30595603 |
Year | 2018 |
Title | Long Non-Coding RNA of Myocardial Infarction Associated Transcript (LncRNA-MIAT) Promotes Diabetic Retinopathy by Upregulating Transforming Growth Factor-β1 (TGF-β1) Signaling. |
Drug-related ncRNA | NO |
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