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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of MIAT
ncRNA name MIAT
ncRNA Category lncRNA
ID 440823
Ensembl ENSG00000225783
Synonyms C22orf35, FLJ25967, LINC00066, NCRNA00066, Rncr2, gomafu, lncRNA-MIAT
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line plasma; human RPE cell line ARPE-19
Methods qRT-PCR, ELISA, MTT assay, Western blot
Expression pattern up-regulated
Functional description Increased plasma levels of lncRNA-MIAT were significantly associated with the presence of diabetic retinopathy, and increased expression of lncRNA-MIAT reduced the viability of ARPE-19 cells in vitro by upregulating TGF-β1 signaling.
PubMed ID 30595603
Year 2018
Title Long Non-Coding RNA of Myocardial Infarction Associated Transcript (LncRNA-MIAT) Promotes Diabetic Retinopathy by Upregulating Transforming Growth Factor-β1 (TGF-β1) Signaling.
Drug-related ncRNA NO

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